We can help you with your concerns. You can learn from us. Henderson Henderson is a city in and the county seat of Vance County in north central North Carolina. The name Henderson is derived from Leonard Henderson, former Chief Justice of the North Carolina Supreme Court. Henderson is known for its rich history, vibrant community, and southern charm. Henderson is characterized by the following. History: Henderson has a deep historical significance, particularly related to its prosperous past as a tobacco and cotton market. Historic buildings in downtown Henderson are a testament to its heritage.Economy: Historically, tobacco and agriculture were ...